Pregnancy changes this organ givingit the capacity to weigh approximately 1,000 g and poten-tially hold approximately 5 L of amniotic ?uid.
As an alternative mechanism, lossof wild-type p53 function has been shown to be due to the dominant-negative effectof mutant p53 .
The pathology underlying this syndrome hasbeen shown to have similarities but also distinctions com-pared to AD. Cervical priming (ripening) Appliedintravaginally or in the cervical canal, low dosesof PGE2 which do not affect uterine motility makethe cervix soft and compliant.
The commonest proteinkinases are the ones which phosphorylate tyrosineresidues on the substrate proteins and are called‘receptor tyrosine kinases’ (RTKs), see Fig.